例句與造句

1. Another example is the research on synthetic lethality in cancer.
2. One or more DNA repair genes in seven DNA repair pathways are frequently synthetic lethality ).
3. Synthetic lethality is also useful for screening libraries of molecules to detect drugs that selectively inhibit cancer cells.
4. High-throughput synthetic lethality screens are also performed in metazoans, but a major challenge is efficient gene perturbation.
5. Synthetic lethality with an identified DNA repair defect in a cancer could thus be a frequent effective method for therapeutic attack on the cancer.
6. It's difficult to find synthetic lethality in a sentence. 用synthetic lethality造句挺難的
7. By examining 5.4 million gene-gene pairs for synthetic lethality, an unbiased network of functional connections between genetic interactions was constructed.
8. Treatments based on the principle of synthetic lethality have prolonged the survival of cancer patients, and show promise for future advances in reversal of carcinogenesis.
9. A major type of synthetic lethality operates on the DNA repair defect that often initiates a cancer, and is still present in the tumor cells.
10. Although treatments using synthetic lethality can stop or slow progression of cancers and prolong survival, each of the synthetic lethal treatments has some adverse side effects.
11. Synthetic lethality with the topoisomerase inhibitor irinotecan appears to occur when given to cancer patients with deficient expression of the DNA repair gene " WRN ".
12. Thus, many ovarian cancers respond to an FDA-approved treatment with a PARP inhibitor, causing synthetic lethality to cancer cells deficient in BRCA1 or BRCA2.
13. These gene networks can be studied by screening for synthetic lethality and gene interactions where a double mutant shows an unexpected fitness value compared to each individual mutant.
14. Screening of 3360 compounds revealed that irinotecan-mediated TOP1 deficiency ( and one other compound, cetrimonium bromide ) exhibit synthetic lethality with NDRG1 deficiency in prostate cancer cells.
15. Synthetic lethality is a consequence of the tendency of organisms to maintain buffering schemes that allow phenotypic stability despite genetic variation, environmental changes and random events such as mutations.
16. Synthetic lethality appears when mutation in a single gene has no effect on the function of cell while mutation in one more additional gene leads to the death of the cell.
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